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sparsentan will decrease the extent or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and reduces efficacy linked to these substrates.Ferraro et al (1997b) examined the in vivo dopamine and GABA levels of the nucleus accumbens in rats pre